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	<title>Comments on: Giant cell pneumonia with DiGeorge syndrome</title>
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	<link>http://pathtalk.org/archives/46</link>
	<description>is a weblog about pathology and laboratory medicine.</description>
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		<title>By: michele oneill</title>
		<link>http://pathtalk.org/archives/46/comment-page-1#comment-1870</link>
		<dc:creator>michele oneill</dc:creator>
		<pubDate>Thu, 25 Aug 2011 22:00:29 +0000</pubDate>
		<guid isPermaLink="false">http://pathtalk.org/archives/46#comment-1870</guid>
		<description>and i&#039;m not sure the telangiectasia...
i&#039;d read that those with complete digeorge have lymphadenopathy and rash..
so would the telangiectasia be from the oligoclonal t cells reaching the surface what i&#039;d read..and what does that mean</description>
		<content:encoded><![CDATA[<p>and i&#8217;m not sure the telangiectasia&#8230;<br />
i&#8217;d read that those with complete digeorge have lymphadenopathy and rash..<br />
so would the telangiectasia be from the oligoclonal t cells reaching the surface what i&#8217;d read..and what does that mean</p>
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	<item>
		<title>By: michele oneill</title>
		<link>http://pathtalk.org/archives/46/comment-page-1#comment-1869</link>
		<dc:creator>michele oneill</dc:creator>
		<pubDate>Thu, 25 Aug 2011 21:56:49 +0000</pubDate>
		<guid isPermaLink="false">http://pathtalk.org/archives/46#comment-1869</guid>
		<description>i see that i have had questions here before...
my question now is...

now my LDL is low, myoglobin is low...i&#039;d been having muscle degeneration increasing in the arms and shoulders seems to be in the connective tissue the dermatology say...there not sure lipoma is what they call it then my d3 came back less then half told me to take 2000 mg a day i had a reaction to that...now there thinking these lipomas are granulation ....i asked what does that mean they&#039;d told me it has to do with the liver...that made sense to me...i&#039;d thought back the rheumatologist i&#039;d seen did not ever hear of di george syndrome and she said is it a liver problem because my d3 is so low...then recently i&#039;ve developed since last february around the time the lumps appeared telangiectasia which were previously petichiae...then i&#039;d read an article about 22q genome project which made reference to herv k provirus ..on a website i&#039;d recently met a women whose baby died from what they called digeorge syndrome and she was wondering why when the dna test results came back there was no deletion...i thought what is the difference i remembered an article on genome 22q herv k provirus and this women whose child died said he had RSV and vaccine didn&#039;t help him...then realized the herv k provirus and rsv are the same thing....so my understanding then the rsv vaccine would not have helped this baby rsv is what was causing his death... and that i think is why you can have di george syndrome without digeorge deletion the common variable i&#039;d just realized was the virus....then further reading retrovirus lead to cancers...thus far science dosn&#039;t know yet...my father died from acute myeloid lukemia and my mother has cutanea tarda porphyria..now i&#039;m 36 my son 15 and daughter 8 we also have von williebrans and 3 of us have 22q.11.2 digeorge syndrome...my sons platelets show large and toxic granulation...i&#039;d read on the above article large platelets and pneumonia...and the necrotizing part rang a bell the primary care doctor thought that&#039;s what was wrong with my arms initially...so what is the retrovirus causing in us what tumors/cancers,, its obvious its at a cellular level...</description>
		<content:encoded><![CDATA[<p>i see that i have had questions here before&#8230;<br />
my question now is&#8230;</p>
<p>now my LDL is low, myoglobin is low&#8230;i&#8217;d been having muscle degeneration increasing in the arms and shoulders seems to be in the connective tissue the dermatology say&#8230;there not sure lipoma is what they call it then my d3 came back less then half told me to take 2000 mg a day i had a reaction to that&#8230;now there thinking these lipomas are granulation &#8230;.i asked what does that mean they&#8217;d told me it has to do with the liver&#8230;that made sense to me&#8230;i&#8217;d thought back the rheumatologist i&#8217;d seen did not ever hear of di george syndrome and she said is it a liver problem because my d3 is so low&#8230;then recently i&#8217;ve developed since last february around the time the lumps appeared telangiectasia which were previously petichiae&#8230;then i&#8217;d read an article about 22q genome project which made reference to herv k provirus ..on a website i&#8217;d recently met a women whose baby died from what they called digeorge syndrome and she was wondering why when the dna test results came back there was no deletion&#8230;i thought what is the difference i remembered an article on genome 22q herv k provirus and this women whose child died said he had RSV and vaccine didn&#8217;t help him&#8230;then realized the herv k provirus and rsv are the same thing&#8230;.so my understanding then the rsv vaccine would not have helped this baby rsv is what was causing his death&#8230; and that i think is why you can have di george syndrome without digeorge deletion the common variable i&#8217;d just realized was the virus&#8230;.then further reading retrovirus lead to cancers&#8230;thus far science dosn&#8217;t know yet&#8230;my father died from acute myeloid lukemia and my mother has cutanea tarda porphyria..now i&#8217;m 36 my son 15 and daughter 8 we also have von williebrans and 3 of us have 22q.11.2 digeorge syndrome&#8230;my sons platelets show large and toxic granulation&#8230;i&#8217;d read on the above article large platelets and pneumonia&#8230;and the necrotizing part rang a bell the primary care doctor thought that&#8217;s what was wrong with my arms initially&#8230;so what is the retrovirus causing in us what tumors/cancers,, its obvious its at a cellular level&#8230;</p>
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		<title>By: michele oneill</title>
		<link>http://pathtalk.org/archives/46/comment-page-1#comment-1509</link>
		<dc:creator>michele oneill</dc:creator>
		<pubDate>Mon, 26 Apr 2010 23:01:53 +0000</pubDate>
		<guid isPermaLink="false">http://pathtalk.org/archives/46#comment-1509</guid>
		<description>i also have recurrent low calcium levels that is inherited with the syndrome as well because of thyroid functions i believe...

i wonder about the possible cause of us having angioedema as result of histamine issues due to the lack of tissue causing this histamine issue i come to this clue because the antibody test i had done had no antibody for strep pneumonias polysacchrides thus, the chain of complementry immune system &quot;polysacchrides&quot; histamine, and the cause for my swelling and joint pain and itching i hate having to figure this stuff out and wish doctors new more then i do about myself</description>
		<content:encoded><![CDATA[<p>i also have recurrent low calcium levels that is inherited with the syndrome as well because of thyroid functions i believe&#8230;</p>
<p>i wonder about the possible cause of us having angioedema as result of histamine issues due to the lack of tissue causing this histamine issue i come to this clue because the antibody test i had done had no antibody for strep pneumonias polysacchrides thus, the chain of complementry immune system &#8220;polysacchrides&#8221; histamine, and the cause for my swelling and joint pain and itching i hate having to figure this stuff out and wish doctors new more then i do about myself</p>
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	<item>
		<title>By: michele oneill</title>
		<link>http://pathtalk.org/archives/46/comment-page-1#comment-1508</link>
		<dc:creator>michele oneill</dc:creator>
		<pubDate>Mon, 26 Apr 2010 22:56:44 +0000</pubDate>
		<guid isPermaLink="false">http://pathtalk.org/archives/46#comment-1508</guid>
		<description>myself 35 f and 2 kids have 22q i think the leukocytopenia was probably high because of the infection these increase because your body was battling the pneumonia... 
many causes of pneumonia for us obviously low t cells etc... but rule out aspiration penumonia this is common for us and could be causing recurrence... also the kidney problems are seen with us also because of lack of development in embryo...</description>
		<content:encoded><![CDATA[<p>myself 35 f and 2 kids have 22q i think the leukocytopenia was probably high because of the infection these increase because your body was battling the pneumonia&#8230;<br />
many causes of pneumonia for us obviously low t cells etc&#8230; but rule out aspiration penumonia this is common for us and could be causing recurrence&#8230; also the kidney problems are seen with us also because of lack of development in embryo&#8230;</p>
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	</item>
	<item>
		<title>By: Kenneth Youens</title>
		<link>http://pathtalk.org/archives/46/comment-page-1#comment-1351</link>
		<dc:creator>Kenneth Youens</dc:creator>
		<pubDate>Fri, 06 Nov 2009 20:20:42 +0000</pubDate>
		<guid isPermaLink="false">http://pathtalk.org/archives/46#comment-1351</guid>
		<description>I think a CMV-negative blood product would be reasonable for a patient like this, though of course circumstances vary.</description>
		<content:encoded><![CDATA[<p>I think a CMV-negative blood product would be reasonable for a patient like this, though of course circumstances vary.</p>
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	<item>
		<title>By: Lindsey N</title>
		<link>http://pathtalk.org/archives/46/comment-page-1#comment-1350</link>
		<dc:creator>Lindsey N</dc:creator>
		<pubDate>Fri, 06 Nov 2009 20:15:21 +0000</pubDate>
		<guid isPermaLink="false">http://pathtalk.org/archives/46#comment-1350</guid>
		<description>Do DiGeorge patients need CMV neg blood products as well?</description>
		<content:encoded><![CDATA[<p>Do DiGeorge patients need CMV neg blood products as well?</p>
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	</item>
	<item>
		<title>By: Kenneth Youens</title>
		<link>http://pathtalk.org/archives/46/comment-page-1#comment-180</link>
		<dc:creator>Kenneth Youens</dc:creator>
		<pubDate>Fri, 04 Jul 2008 17:04:14 +0000</pubDate>
		<guid isPermaLink="false">http://pathtalk.org/archives/46#comment-180</guid>
		<description>Yes, since DiGeorge syndrome results in a severe deficit in cell-mediated immunity, irradiation of transfused platelets is needed to prevent a graft-verus-host process.</description>
		<content:encoded><![CDATA[<p>Yes, since DiGeorge syndrome results in a severe deficit in cell-mediated immunity, irradiation of transfused platelets is needed to prevent a graft-verus-host process.</p>
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	<item>
		<title>By: vlado cernak</title>
		<link>http://pathtalk.org/archives/46/comment-page-1#comment-179</link>
		<dc:creator>vlado cernak</dc:creator>
		<pubDate>Fri, 04 Jul 2008 13:46:02 +0000</pubDate>
		<guid isPermaLink="false">http://pathtalk.org/archives/46#comment-179</guid>
		<description>If thw pt. needs trombocyte transfusion I assume they must be irradiated too?</description>
		<content:encoded><![CDATA[<p>If thw pt. needs trombocyte transfusion I assume they must be irradiated too?</p>
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	<item>
		<title>By: Sergio Xavier</title>
		<link>http://pathtalk.org/archives/46/comment-page-1#comment-158</link>
		<dc:creator>Sergio Xavier</dc:creator>
		<pubDate>Fri, 22 Feb 2008 00:27:21 +0000</pubDate>
		<guid isPermaLink="false">http://pathtalk.org/archives/46#comment-158</guid>
		<description>and the hypocalcemia is secondary to parathyroid aplasia.</description>
		<content:encoded><![CDATA[<p>and the hypocalcemia is secondary to parathyroid aplasia.</p>
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	<item>
		<title>By: Sergio Xavier</title>
		<link>http://pathtalk.org/archives/46/comment-page-1#comment-157</link>
		<dc:creator>Sergio Xavier</dc:creator>
		<pubDate>Fri, 22 Feb 2008 00:23:07 +0000</pubDate>
		<guid isPermaLink="false">http://pathtalk.org/archives/46#comment-157</guid>
		<description>There may be problems with the immune system - in particular, T-lymphocytes may not function properly, leading to frequent infections.</description>
		<content:encoded><![CDATA[<p>There may be problems with the immune system &#8211; in particular, T-lymphocytes may not function properly, leading to frequent infections.</p>
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