Comments on: Giant cell pneumonia with DiGeorge syndrome

By: michele oneill

michele oneill — Mon, 26 Apr 2010 23:01:53 +0000

i also have recurrent low calcium levels that is inherited with the syndrome as well because of thyroid functions i believe…

i wonder about the possible cause of us having angioedema as result of histamine issues due to the lack of tissue causing this histamine issue i come to this clue because the antibody test i had done had no antibody for strep pneumonias polysacchrides thus, the chain of complementry immune system “polysacchrides” histamine, and the cause for my swelling and joint pain and itching i hate having to figure this stuff out and wish doctors new more then i do about myself

By: michele oneill

michele oneill — Mon, 26 Apr 2010 22:56:44 +0000

myself 35 f and 2 kids have 22q i think the leukocytopenia was probably high because of the infection these increase because your body was battling the pneumonia…
many causes of pneumonia for us obviously low t cells etc… but rule out aspiration penumonia this is common for us and could be causing recurrence… also the kidney problems are seen with us also because of lack of development in embryo…

By: Kenneth Youens

Kenneth Youens — Fri, 06 Nov 2009 20:20:42 +0000

I think a CMV-negative blood product would be reasonable for a patient like this, though of course circumstances vary.

By: Lindsey N

Lindsey N — Fri, 06 Nov 2009 20:15:21 +0000

Do DiGeorge patients need CMV neg blood products as well?

By: Kenneth Youens

Kenneth Youens — Fri, 04 Jul 2008 17:04:14 +0000

Yes, since DiGeorge syndrome results in a severe deficit in cell-mediated immunity, irradiation of transfused platelets is needed to prevent a graft-verus-host process.

By: vlado cernak

vlado cernak — Fri, 04 Jul 2008 13:46:02 +0000

If thw pt. needs trombocyte transfusion I assume they must be irradiated too?

By: Sergio Xavier

Sergio Xavier — Fri, 22 Feb 2008 00:27:21 +0000

and the hypocalcemia is secondary to parathyroid aplasia.

By: Sergio Xavier

Sergio Xavier — Fri, 22 Feb 2008 00:23:07 +0000

There may be problems with the immune system – in particular, T-lymphocytes may not function properly, leading to frequent infections.

By: Roger E

Roger E — Sat, 17 Nov 2007 06:47:34 +0000

I am an adult age 47 with DiGeorge Syndrome. I have had 3 attacks of Pneumonia in the past 18 months. I have Hypoparathyroidism along with severe Hypocalcemia and I sometimes have leukocytosis.

I receive calcium infusions 3 times per week because my calcium levels crash immediately. I am then subject to Carpopedal spasm and Grand Mal Seizures for which I have had many. Each Grand Mal Seizure gets progressively worse with each attack.

I now have Chronic Kidney Disease Stage 3 due to Nephrocalcinosis of the Kidneys. I have a small right kidney. It is 3 times smaller than the left Kidney.

I also have Osteoporosis (Verified by Bone Biopsy) along with Vitamin D Deficiency and Osteoarthiris and Gout with elevated Uric Acid levels in the high range.

Does anyone have a clue as to why I would have recurring attacks of Pneumonia with Leukocytosis and Hypocalcemia? Are all of these issues linked to DiGeorge Syndrome?

By: PathDoc15

PathDoc15 — Sat, 03 Nov 2007 20:00:29 +0000

Interestingly, DiGeorge syndrome is actually not uncommon at all: incidence of about 1:4000 to 1:6000 live births (reference below). It is a very common etiology of cardiac defects in new borns (can’t remember the number right now…). Also about 8% of babies with cleft palate have DiGeorge.

Check out http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&list_uids=12837874&dopt=AbstractPlus“>this link.