I recently did a brain autopsy on a 70-year-old woman who died from an intraparenchymal brain hemorrhage after a seven-year history of progressive dementia. The gross photograph follows: I know what you’re thinking: an amyloid angiopathic bleed, or perhaps a hypertensive bleed, in a patient with Alzheimer disease. That’s what I was thinking until I [...]
The following is a giemsa-stained air-dried smear of CSF from a comatose 14 year boy. He had been in his normal state of health up until the day previous, when he experienced rapidly declining mental status. The forms seen were the only ones present, and measure approximately 20 micrometers in diameter. Identification?
If you consider yourself a blue-collar neuropathologist, a nice resource has appeared on the web for you. Henry Stewart Publications, based in London, is providing free access to a wide variety of on-line biomedical lectures in the form of the Henry Stewart Talks. Many different biomedical topics are addressed, but one series focuses on neurodegenerative [...]
Welcome back to the Parasite Case of the Week! I post a new case every Monday, along with the answer to the previous week’s case. Here is our new case for this week. It is a bit more straight-forward than last week’s case: The following object was identified in the diaper of an infant by [...]
A common theme among neurodegenerative diseases is that there is a some kind of “nucleating protein” which aggregates within specific areas of the brain. There is debate as to whether the aggregates cause disease, or are simply an attempt by brain cells to sequester bad proteins. If the former is true, then therapy should be [...]
The patient is a 75-year-old male who reported to his ophthalmologist complaining of failing vision as well as intermittent “flashes of light” in his left eye over the previous four months. Examination of the left eye revealed markedly elevated intraocular pressure. Fundiscopic examination revealed a large grayish brown subretinal mass with surrounding retinal folds in [...]
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