Warfarin is one of the most commonly prescribed anticoagulants for prophylaxis and treatment of venous and arterial thromboembolic disorders or those at high risk for such disorders. Warfarin also has an FDA-issued “Black Box” warning for a high risk of fatal bleeding, most commonly from the gastrointestinal tract and in the brain. It acts by [...]
Clinical History A 7 month-old male was admitted for severe pneumonia with respiratory compromise. Laboratory studies demonstrated leukocytosis and profound hypocalcemia. An inherited immunodeficiency syndrome was suspected. A CT scan of the chest revealed bilateral lobar pneumonia, and no thymus was seen. Dual-probe fluoresence in-situ hybridization for deletions of 10p13p14 and 22q11.2 was performed on [...]
Testing-testing: CGH me baby: I want to know how I measure up to the reference. This is a very superficial post touching on an increasingly utilized testing methodology. Comparative genomic hybridization (CGH) (also has been called “competitive”) is a method for scanning the entire genome for variations in DNA copy number which is not currently [...]
Via Keith Kaplan’s Digital Pathology Blog, I found the website for Objective Pathology, a telepathology organization “focused on enhancing and accelerating educational and diagnostic pathology workflows”. There is a lot of good stuff at their site, but my favorite is the narrated virtual slide tours – there is an example of multiple myeloma here. This [...]
The front page of the Wall Street Journal got a little buzz yesterday from the health care community, medical bloggers and the pathology residency program directors among them. It profiled West Virginia primary care doc Vic Wood, who has reinvented his practice by offering “prepaid” services: For a monthly fee of $83 per individual or [...]
The ASCP daily newsletter dated 10/12/07 had a short paragraph about home kit DNA diagnostics. Risk assessment for tailored treatment plans is a marketing strategy supporting the use of DIY (do-it-yourself) DNA swabs fishing for SNPs (single nucleotide polymorphisms) deemed as high risk in some common diseases such as atrial fibrillation. The current prevalence of [...]
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