If you consider yourself a blue-collar neuropathologist, a nice resource has appeared on the web for you. Henry Stewart Publications, based in London, is providing free access to a wide variety of on-line biomedical lectures in the form of the Henry Stewart Talks. Many different biomedical topics are addressed, but one series focuses on neurodegenerative [...]
In the the current issue of Archives of Pathology and Laboratory Medicine, a team including Bette K. Kleinschmidt-DeMasters, MD authored an interesting article entitled Rare Nerve Lesions of Non-Nerve Sheath Origin: a 17-year Retrospective Series. DeMasters, neuropathology chief at the University of Colorado in Denver, and her team did a computer search of all peripheral [...]
The patient is a 75-year-old male who reported to his ophthalmologist complaining of failing vision as well as intermittent “flashes of light” in his left eye over the previous four months. Examination of the left eye revealed markedly elevated intraocular pressure. Fundiscopic examination revealed a large grayish brown subretinal mass with surrounding retinal folds in [...]
Most of us accept the party line that there are three basic forms of Creutzfeldt-Jakob disease (CJD): acquired, inherited, and sporadic. The general neurology and neuropathology textbooks do not acknowledge that the very existence of sporadic CJD is controversial. But D.T. Max (picture from nytimes.com), in his book The Family That Couldn’t Sleep: A Medical [...]
One of our lab techs posed a question about beta-2 transferrin testing on cerebrospinal fluid (CSF). Because beta-2 transferrin is a normal constituent of CSF, but not of plasma or mucosal secretions, it is useful in determining whether a patient’s nose or ear is leaking CSF versus some other fluid. This is important in determining [...]
We received a muscle biopsy recently from a 5-year-old girl who was likely a dystrophin mutation carrier. Her muscle biopsy displayed a patchwork pattern of dystrophin positive and dystrophin negative muscle fibers. Utrophin was upregulated in fibers deficient for dystrophin. So, what is utrophin? It is the autosomal homologue of dystrophin. To quote the Dubowitz [...]
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